Gilead Sciences has reported additional data from the testing of its experimental antiviral drug remdesivir in patients with Covid-19 infection.
The data include findings from a comparative analysis of the Phase III SIMPLE-Severe clinical trial and a real-world retrospective cohort of patients with a severe form of the disease.
According to the analysis, the drug demonstrated an improvement in clinical recovery and a 62% reduction in the risk of mortality compared to standard of care.
Separate analyses were conducted of subgroups from the Phase III SIMPLE-Severe trial, including a review of the safety and efficacy of remdesivir in various racial and ethnic patient subgroups treated in the US.
Data from these analyses revealed that traditionally marginalised racial or ethnic groups who received the drug had similar clinical outcomes as the overall patient population.
In addition, analyses of Gilead’s compassionate use programme showed recovery by day 28 in 83% of paediatric patients and 92% of pregnant and postpartum women with a broad spectrum of disease severity.
The investigators did not report any new safety signals with remdesivir in these populations. – Clinical Trials Arena