Mateon Announces the Filing Of An IND With US FDA To Evaluate Its Antisense Drug Candidate OT-101 In COVID-19 Patients

Mateon Therapeutics, Inc. (OTCQB:MATN) announced today it has submitted an Investigational New Drug (IND) application to the US Food and Drug Administration (FDA) to study its investigational drug, OT-101, for the treatment of COVID-19 pandemic.

The proposed randomized, double-blind, placebo-controlled Phase 2 study is intended to evaluate the safety and efficacy of OT-101 in adult patients hospitalized with COVID-19 and pneumonia in the US.

OT-101 is a potent inhibitor of SAR-CoV2 replication with efficacy and safety index on par or superior to Remdesivir- a Gilead’s drug. Unlike Remdesivir- OT-101 targets not only the virus replication but also the often lethal clinical sequelae of COVID-19, including pneumonia and fibrosis.  OT-101 is a proprietary, first-in-class, TGF-β antisense with broad efficacy against solid tumors including pancreatic cancer, glioblastoma, and melanoma across multiple phase 2 oncology trials.

“We are advancing quickly the clinical development of OT-101 as multimodal drug against COVID-19.  It is imperative to look at a basket of drug candidates to insure finding the cure for COVID-19.  Additionally, an effective treatment for COVID-19 is more likely a cocktail of drugs,” said Dr Vuong Trieu, CEO of Mateon Therapeutics. “We look forward to collaborating closely with leading clinical investigators and the FDA to validate the effectiveness of OT-101 in treating COVID-19 in a controlled clinical setting.”-Globe Newswire