The rising oligonucleotide synthesis market powering healthcare

Oligonucleotides, commonly made in a laboratory, are short DNA or RNA molecules known as oligomers or oligos that have a wide range of applications in genetic testing, research, and forensics.

Oligonucleotide synthesis involves the chemical synthesis of nucleic acids in small fragments of a defined sequence or chemical structure, using the phosphoramidites. This approach is useful in current laboratory practice as it offers inexpensive and rapid access to custom-made oligonucleotides of the desired target sequence. Modification of oligonucleotides primers (5’ and/or 3’) has been exploited for various applications, including real-time PCR and drug discovery research. TaqMan probes are mostly used in modified oligonucleotide probes for the qualitative and/or quantitative real-time PCR reaction. The oligonucleotides primers and probes are the backbone of molecular diagnosis and molecular biology-based research of several diseases, including hepatitis, SARS-CoV-2, infectious diseases, cancer diagnosis, biotechnology research, therapeutics, forensic, and drug discovery.

Apart from diagnostics and drug discovery, customized oligo synthesis is the first step of genetic engineering, site-directed mutagenesis, and many other applications. In fact, development of various RNA/DNA-based vaccines also utilizes the customization of oligos for the required modifications.

According to the latest report, the global oligonucleotide synthesis market in 2020 was valued at USD 5197.50 million, and by registering a CAGR of 17.10 percent from 2021 to 2030, it is projected to reach USD 26,099.90 million by 2030. By application, it is assorted into research applications, therapeutic applications, and diagnostic applications.

The global oligonucleotide synthesis market revenue growth is primarily credited to factors, such as the increasing prevalence of acute and chronic diseases, demand for personalized medicine, and increasing therapeutic applications of synthesized oligos. Oligonucleotide probes are used to detect single base pair variation within the human genome. These oligo products are also required for the development of kits, restoratives, and vaccines. The promising potential of synthesized oligonucleotides in various fields drives the market growth.

During the outbreak of Covid-19, there has been a surge in demand for various medical services, including the oligonucleotide products. The pandemic has catalyzed the demand for oligonucleotide synthesis products, which are being widely used in the development of coronavirus vaccines, test kits, and therapeutics. There has been impetus in local manufacturing of these components and the government is hence investing and focusing on synthetic biology, genome projects, and the research that drives the oligonucleotide system market.

Trivitron Healthcare takes pride in being one of the premier organizations to have developed oligo pools, and high-diversity collections of oligonucleotides, which are utilized in diverse applications. It offers precise editing of target loci as it enables highly accurate synthesis for specific targeting with a very low error rate. The oligos can be custom synthesized as per the specific requirements. They can be conventionally used in PCR, RT-PCR kits, next-generation sequencing panels, adaptors, indices, cloning, and positive as well as negative controls. With years of depth experience in chemical synthesis of all formats of oligo and other chemistry, the synthesis performed in advanced genomics labs and oligos produced in the Trivitron facility meet the required quality standards.